Selected Research Publications

To download PDFs of the following selected journal articles published by Dr. Brem and his research colleagues, click on the title of each individual article.

Clinical Applications of Growth Factors and Cytokines in Wound Healing. Stephan Barrientos, Harold Brem, Olivera Stojadinovic, Marjana Tomic-Canic. Wound Repair and Regeneration, unproofed manuscript.

Deep Tissue Injury in Development of Pressure Ulcers: A Decrease in Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load. Olivera Stojadinovic, Julia Minkiewicz, Andrew Sawaya, Jonathan W. Bourne, Peter Torzilli, Juan Pablo de Rivero Vaccari, W. Dalton Dietrich, Robert W. Keane, Marjana Tomic-Canic. Plos One, August 2013; 8(8) e69223 1-9.

Regional Anaesthesia with Sedation Protocol to Safely Debride Sacral Pressure Ulcers. Daniel K. O’Neill, Bryan Robins, Elizabeth A . Ayello, Germaine Cuff, Patrick Linton, Harold Brem. International Wound Journal, Oct. 2012; 9(5): 525-543.

Induction of Specific MicroRNAs Inhibits Cutaneous Wound Healing. Irena Pastar, Aly Azeem Khan, Olivera Stojadinovic, Elizabeth A. Lebrun, Mayrin Correa Medina, Harold Brem, Robert S. Kirsner, Joaquin J. Jimenez, Christina Leslie, Marjana Tomic-Canic. Journal Of Biological Chemistry, Aug. 24, 2012; 287(35): 29324–29335.

Cortisol Synthesis in Epidermis is Induced by IL-1 and Tissue Injury. Sasa Vukelic, Olivera Stojadinovic, Irena Pastar, Morgan Rabach, Agata Krzyzanowska, Elizabeth Lebrun, Stephen C. Davis, Sydney Resnik, Harold Brem, Marjana Tomic-Canic. Journal of Biological Chemistry, March 25, 2011; 286(12): 10265–10275.

High Cost of Stage IV Pressure Ulcers. Harold Brem, Jason Maggi, David Nierman, Linda Rolnitzky, David Bell, Robert Rennert, Michael Golinko, Alan Yan, Courtney Lyder, Bruce Vladeck. The American Journal of Surgery, Oct. 2010; 200: 473–477.

Attenuation of the Transforming Growth Factor β–Signaling Pathway in Chronic Venous Ulcers. Irena Pastar, Olivera Stojadinovic, Agata Krzyzanowska, Stephan Barrientos, Christina Stuelten, Karen Zimmerman, Miroslav Blumenberg, Harold Brem, Marjana Tomic-Canic. Molecular Medicine, March-April 2010; 16(3-4): 92-101.

Preliminary Development of a Diabetic Foot Ulcer Database from a Wound Electronic Medical Record: A Tool to Decrease Limb Amputations. Michael S. Golinko, David J. Margolis, Adit Tal, Ole Hoffstad, Andrew J. M. Boulton, Harold Brem. Wound Repair and Regeneration, Sept–Oct 2009.; 17(5): 657-665.

Mechanism of Sustained Release of Vascular Endothelial Growth Factor in Accelerating Experimental Diabetic Healing. Harold Brem, Arber Kodra, Michael S. Golinko, Hyacinth Entero, Olivera Stojadinovic, Vincent M. Wang, Claudia M. Sheahan, Alan D. Weinberg, Savio L.C. Woo, H. Paul Ehrlich, Marjana Tomic-Canic. Journal of Investigative Dermatology, Sept. 2009; 129(9):2275-2287.

Surgical Pathology to Describe the Clinical Margin of Debridement of Chronic Wounds Using a Wound Electronic Medical Record. Michael S Golinko, Renata Joffe, David deVinck, Eashwar Chandrasekaran, Olivera Stojadinovic, Stephan Barrientos, SasaVukelic, MarjanaTomic-Canic, Harold Brem. Journal of the American College of Surgeons, Aug. 2009; 209(2): 254-260.e1.

Operative Debridement of Pressure Ulcers. Jessica Schiffman, Michael S. Golinko, Alan Yan, Anna Flattau, Marjana Tomic-Canic, Harold Brem. World Journal of Surgery, July 2009; 33(7): 1396–1402.

Wound Emergencies: The Importance of Assessment, Documentation, and Early Treatment Using a Wound Electronic Medical Record. Michael S. Golinko, Sunday Clark, Robert Rennert, Anna Flattau, Andrew J. M. Boulton, Harold Brem. Ostomy Wound Management, May 2009; 55(5): 54-61.

The Role of Vascular Endothelial Growth Factor in Wound Healing. Philip Bao, Arber Kodra, Marjana Tomic-Canic, Michael S. Golinko, H. Paul Ehrlich, Harold Brem. Journal of Surgical Research, May 15, 2009; 153(2): 347-358.

Developing and Evaluating Outcomes of an Evidence-based Protocol for the Treatment of Osteomyelitis in Stage IV Pressure Ulcers: A Literature and Wound Electronic Medical Record Database Review. Robert Rennert, Michael Golinko, Alan Yan, Anna Flattau, Marjana Tomic-Canic, Harold Brem. Ostomy Wound Management, March 2009; 55(3): 42-53.

Standardization of Wound Photography Using the Wound Electronic Medical Record. Robert Rennert, Michael Golinko, Dave Kaplan, Anna Flattau, Harold Brem. Advances in Skin & Wound Care, Jan. 2009; 22(1): 32-38.

Operative Debridement of Diabetic Foot Ulcers. Michael S. Golinko, Renta Joffe, Jason Maggi, Dalton Cox, Eashwar B. Chandrasekaran, MS, R. Marjana Tomic-Canic, Harold Brem. Journal of the American College of Surgeons, Dec. 2008; 207(6): e1-e6.

Antibiotic-Resistant Gram-Negative Bacteria in Deep Tissue Cultures. Anna Flattau, Jessica Schiffman, Franklin D. Lowy, Harold Brem. International Wound Journal, Dec. 2008; 5(5): 599-600.

Using Gene Transcription Patterns (Bar Coding Scans) to Guide Wound Debridement and Healing. Marjana Tomic-Canic, Elizabeth A. Ayello, Olivera Stojadinovic, Michael S. Golinko, Harold Brem. Advances in Skin & Wound Care, Oct. 2008; 21(10): 487-494.

Growth Factors and Cytokines in Wound Healing. Stephan Barrientos, Olivera Stojadinovic, Michael S. Golinko, Harold Brem, Marjana Tomic-Canic. Wound Repair and Regeneration, Sept-Oct 2008; 16(5): 585-601.

ADAM12: A Potential Target for the Treatment of Chronic Wounds. Asheesh Harsha, Olivera Stojadinovic, Harold Brem, Atsuko Sehara-Fujisawa, Ulla Wewer, Cynthia A. Loomis, Carl P. Blobel, Marjana Tomic-Canic. Journal of Molecular Medicine, Aug. 2008; 86(8): 961-969.

Primary Cultured Fibroblasts Derived from Patients with Chronic Wounds: A Methodology to Produce Human Cell Lines and Test Putative Growth Factor Therapy Such As GMCSF. Harold Brem, Michael S. Golinko, Olivera Stojadinovic, Arber Kodra, Robert F. Diegelmann, Sasa Vukelic, Hyacinth Entero, Donald L. Coppock, Marjana Tomic-Canic. Journal of Translational Medicine, 2008; 6:75.

The Synergism of Age and db/db Genotype Impairs Wound Healing. Harold Brem, Marjana Tomic-Canic, Hyacinth Entero, Andrew M. Hanflik, Vincent M. Wang, John T. Fallon, H. Paul Ehrlich. Experimental Gerontology 2007; 42(6): 523-531

Cellular and Molecular Basis of Wound Healing in Diabetes. Harold Brem, Marjana Tomic-Canic. The Journal of Clinical Investigation, May 2007; 117(5): 1219-22.

Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement. Harold Brem, Olivera Stojadinovic, Robert F Diegelmann, Hyacinth Entero, Brian Lee, Irena Pastar, Michael Golinko, Harvey Rosenberg, and Marjana Tomic-Canic. Molecular Medicine, Jan-Feb 2007; 13(1-2): 30–39.

Evidence-Based Protocol for Diabetic Foot Ulcers. Harold Brem, Peter Sheehan, Harvey J. Rosenberg, Jillian S. Schneider, Andrew J. M. Boulton. Plastic and Reconstructive Surgery, June Supplement 2006; 117(7S): 193S-209S.

Molecular Pathogenesis of Chronic Wounds: The Role of β-Catenin and c-myc in the Inhibition of Epithelialization and Wound Healing. Olivera Stojadinovic, Harold Brem, Constantinos Vouthounis, Brian Lee, John T. Fallon, Michael Stallcup, Ankit Merchant, Robert D. Galiano, Marjana Tomic-Canic. American Journal of Pathology, July 2005; 167(1): 59-69.

Practical Treatment of Pain in Patients with Chronic Wounds: Pathogenesis-Guided Management. Gordon Freedman, Hyacinth Entero, Harold Brem. American Journal of Surgery, July 2004; 188 (1A Suppl): 31-35.

Protocol for the Successful Treatment of Pressure Ulcers. Harold Brem, Courtney Lyder. American Journal of Surgery, July 2004; 188 (1A Suppl): 9-17.

Pathogenesis and Treatment of Pain in Patients with Chronic Wounds. Gordon Freedman, Conrad Cean, Vincent Duron, Alina Tarnovskaya, Harold Brem. Surgical Technology International 2003; 11: 168-179.

Healing of Elderly Patients with Diabetic Foot Ulcers, Venous Stasis Ulcers, and Pressure Ulcers. Harold Brem, Marjana Tomic-Canic, Alina Tarnovskaya, H. Paul Ehrlich, Edwina Baskin-Bey, Kiran Gill, Miriam Carasa, Sarah Weinberger, Hyacinth Entero, Bruce Vladek. Surgical Technology International 2003; 11: 161-167.

Clinical Efficacy and Mechanism of Bilayered Living Human Skin Equivalent (HSE) in Treatment of Diabetic Foot Ulcers. Harold Brem, Jan Young, Marjana Tomic-Canic, Cary Isaacs, H. Paul Ehrlich. Surgical Technology International 2003; 11: 23-31.

Pressure Ulcers in the Chronically Critically Ill Patient. Harold Brem, David M. Nierman, Judith E. Nelson. Critical Care Clinics, July 2002; 18(3): 683– 694.

Healing of Diabetic Foot Ulcers and Pressure Ulcers with Human Skin Equivalent: A New Paradigm in Wound Healing. Harold Brem, Jeroen Balledux, Tamir Bloom, Morris D. Kerstein, Larry Hollier. Archives of Surgery, June 2000; 135(6): 627-634.

Analysis of Experimental Anti-Angiogenic Therapy. Harold Brem, Judah Folkman. Journal of Pediatric Surgery, March 1993; 28(3): 445-451.

item1a1
item1a1a
item1
item1 item1
item1
item1 HOURS AND CONTACT INFO item1 DIRECTIONS AND MAP item1 PATIENT STORIES item1
item1
item11
item3